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Enzybiotics: Antibiotic Enzymes as Drugs and Therapeutics by Tomas G. Villa, Patricia Veiga Crespo

By Tomas G. Villa, Patricia Veiga Crespo

Offers the newest examine and purposes for a brand new, promising method of battling infectious diseasesEnzybiotics is a promising manner of struggling with bacterial or fungal infectious ailments by utilizing viruses or viral-derived lysins. Drawing from the fields of medicinal chemistry, microbiology, genetics, and biochemistry, this booklet provides the country of the technological know-how in enzybiotics study, totally exploring its rising healing applications.The publication starts with 4 chapters that evaluate the aptitude functions, attainable merits, and phylogeny of enzybiotics. subsequent, the ebook explores: a brand new method of controlling infections utilizing Gram-negative bacteriaBacteriophage holins and their membrane-disrupting activityAnti-staphylococcal lytic enzymesMembrane-targeted enzybioticsDesign of phage cocktails for remedy from a host-range element of viewNovel ways to establish new enzybioticsGenetically converted phages that convey suicidal genes to focus on bacteriaThe authors, all energetic enzybiotics researchers, supply numerous views, the good thing about their very own hands-on investigations, in addition to a radical evaluation and research of the present literature.As increasingly more micro organism turn into proof against antibiotics, the advance of recent disease-fighting brokers has develop into crucial. This booklet demonstrates the complete capability of the rising box of enzybiotics to manage infectious ailments. furthermore, it's going to function a springboard for brand new learn and the improvement of recent therapeutics.

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Schuch, D. Nelson, and V. A. Fischetti (2006) Journal of Bacteriology 188, 2711–2714. Young R. -N. Wang, and W. D. Roof (2000) Trends in Microbiology 8, 120–128. , N. Vukov, S. Scherer, and M. J. Loessner (2002) Applied and Environmental Microbiology 68, 5311–5317. CHAPTER 2 ADVANTAGES AND DISADVANTAGES IN THE USE OF ANTIBIOTICS OR PHAGES AS THERAPEUTIC AGENTS PATRICIA VEIGA-CRESPO1 and TOMAS G. VILLA1,2 1 Departament of Microbiology, Faculty of Pharmacy, University of Santiago de Compostela, Spain 2 School of Biotechnology, University of Santiago de Compostela, Spain 1.

J. Coote (2007) Journal of Antimicrobial Chemotherapy 59, 759–762. , J. M. Loeffler, V. A. Fischetti, and S. L. Leib (2008) The Journal of Infectious Diseases 197, 1519–1522. Gründling A, D. M. Missiakas, and O. Schneewind (2006) Journal of Bacteriology 188, 6286–6297. Hawkey P. M. (2008) Journal of Antimicrobial Chemotherapy 62 (Suppl. 1), 1–9. 24 ENZYBIOTICS AND THEIR POTENTIAL APPLICATIONS IN MEDICINE Heath L. , H. E. Heath, P. A. LeBlanc, S. Rochelle Smithberg, M. Dufour, R. S. Simmonds, and G.

CONCLUDING REMARKS Many experimental studies performed both in vitro and in vivo have shown that enzybiotics constitute highly effective antibacterial agents. 22 ENZYBIOTICS AND THEIR POTENTIAL APPLICATIONS IN MEDICINE In view of the dramatic and continuing increase in the prevalence of multidrug-resistant bacteria, the most important features of enzybiotics are their novel mode of action and the capability to kill antibioticresistant bacteria. Moreover, at least for some lytic enzymes, the risk of developing resistance is relatively lower than for traditional antibiotics.

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