alpha brooks Book Archive


Drug-Induced Pathology by H. Jick (auth.), E. Grundmann (eds.)

By H. Jick (auth.), E. Grundmann (eds.)

Show description

Read or Download Drug-Induced Pathology PDF

Best pathology books

Blaustein’s Pathology of the Female Genital Tract

Because the book of the 1/e in 1977, Blaustein's Pathology of the feminine Genital Tract has consolidated its place because the prime textbook of gynecological pathology. a necessary reference for all pathologists and citizens, this completely up-to-date 6th version comprises greater than 1400 illustrations in colour, informative tables and 22 revised chapters written by means of the world over well-known specialists.

Germination Control. Metabolism, and Pathology

Seed Biology, quantity II: Germination keep watch over, Metabolism, and Pathology is part of a three-volume treatise, which goals to assemble a wide physique of vital info on seed biology. equipped into 5 chapters, this publication starts off with a dialogue on environmental keep an eye on of germination and its organic importance.

The Human Body in Health and Disease

The Human physique in healthiness and affliction is designed as a quick path protecting the fundamentals of human anatomy and body structure with an emphasis at the mechanisms of illness. The booklet contains easy suggestions of anatomy and body structure, built-in disease-related details, scientific functions, and terminology — all with out over the top aspect.

Oxford handbook of clinical pathology

The Oxford instruction manual of medical Pathology offers an obtainable and easy-to-use guide for scientific scholars and medical professionals, which succinctly explains the pathology at the back of vital and customary illnesses appropriate to the total variety of scientific and surgical specialties. It covers easy basic pathological ideas and follows a systems-based technique, highlighting the most typical stipulations in every one zone.

Additional info for Drug-Induced Pathology

Sample text

26 These results are indirectly supported by a report of the Boston Collaborative Drug Surveillance Program (BCDSP) (1973a). 8% of 234 patients with a normal serum albumin, despite a similar average phenytOin dose in the two groups. The authors advanced the hypothesis that decreased binding of phenytoin to serum albumin was responsible for their findings, and a negative correlation between plasma albumin level and unbound fraction of phenytOin has been confirmed in a subsequent study (Porter and Layzer 1975).

In these conditions the rate of formation of the toxic precursor(s) exceeds the availability of reduced glutathione and cell necrosis occurs. Indeed, a positive correlation between the amount of cysteine and mercapturic acid conjugates in urine (expressed as a fraction of total metabolites recovered) and the severity of liver damage has been described in patients admitted to hospital after a paracetamol overdose (Davis et al. 1976). A mechanism similar to that discussed for paracetamol is probably responsible for the dose-dependent hepatotoxicity and nephrotoxicity of frusemide (Mitchell et al.

There is increasing evidence that the higher susceptibility of elderly patients to adverse drug reactions cannot solely be explained on the basis of pharmacokinetic differences such as impaired elimination or decreased plasma-protein binding. Bender (1964) has advocated the development in the elderly of an increased drug sensitivity at the receptor site. The adverse reactions to barbiturates so frequently observed in geriatric patients are likely to be due to this mechanism (O'Malley et al. 1976).

Download PDF sample

Rated 4.42 of 5 – based on 28 votes