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Domino Reactions in Organic Synthesis by Lutz F. Tietze, Hubertus P. Bell, Gordon Brasche

By Lutz F. Tietze, Hubertus P. Bell, Gordon Brasche

Domino reactions assist you construct advanced constructions in one-pot reactions with no the necessity to isolate intermediates—a dream comes actual. during this publication, the well-respected professional, Professor Lutz Tietze, summarizes the chances of this response type—an technique for an efficiant, economically benificial and ecological benign synthesis.
A certain needs to for each natural chemist.

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Over the years, intensive studies in medicinal chemistry with regard to the structure−activity relationships of compounds being used in clinical praxis have revealed the exceptional position of heterocycles. Moreover, a multitude of bioactive natural products contain a heteroatom. t. 26. Cationic domino rearrangement/cyclopropanation process for the total synthesis of (+)-isovelleral (1-103). 27. Cationic domino transformation towards the synthesis of azadirachtin (1-105). methods for constructing heterocyclic frameworks is of major importance, and it is of no wonder that several cationic domino processes have been designed in this field.

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