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Difficult Diagnoses in Breast Pathology by Juan P. Palazzo MD

By Juan P. Palazzo MD

Breast melanoma is the second one best reason for melanoma dying in ladies within the usa. For the pathologist, virtually any breast lesion could produce diagnostic trouble, in particular because of usually small samples (core biopsy specimens) and numerous mimics and variations obvious in particular kinds of lesions. also, the trouble of breast lesion analysis has risen dramatically lately because of the elevated emphasis on stratifying sufferers for applicable remedy on someone foundation; the broader variety of either neighborhood and systemic healing innovations, and the possibility of past prognosis via elevated mammographic breast screening resulting in a better probability of a good final result.

Difficult Diagnoses in Breast Pathology offers a hugely visible presentation of the key difficulties and questions pathologist is probably going to come across within the overview of universal and unusual breast ailments. assurance contains needle center biopsy interpretation, prognosis of precursor lesions, early level affliction, and popularity of neoplastic mimics and different deceptive variations. furthermore, this ebook emphasizes fairly tough parts together with using more moderen immunohistochemical markers. all through, the emphasis is on an simply obtainable presentation with tables and lists of key issues summarizing significant findings and various fine quality pictures aiding the textual content. Difficult Diagnoses in Breast Pathology could be a precious reference for each pathologist who bargains with the analysis of breast ailments.

Difficult Diagnoses in Breast Pathology Features:

  • Each bankruptcy authored via well-known specialist within the quarter
  • Hundreds of top of the range photographs
  • Tables and key issues in every one bankruptcy summarize an important findings
  • Coverage in response to addressing intimately the real-world diagnostic difficulties the pathologist will face in day-by-day perform

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Extra resources for Difficult Diagnoses in Breast Pathology

Example text

Ductal hyperplasia at ultrasound-guided core needle biopsy. Breast Cancer Res Treat. 2008;112:189–195. 7. Eby PR, Ochsner JE, DeMartini WB, Allison KH, Peacock S, Lehman CD. Is surgical excision necessary for focal atypical ductal hyperplasia found at stereotactic vacuum assisted breast biopsy? Ann Surg Oncol. 2008;15:545–550. 8. Sneige N, Lim SC, Whitman GJ, et al. Atypical ductal hyperplasia diagnosis by directional vacuum-assisted stereotactic biopsy of breast microcalcifications. Considerations for surgical excision.

If ADH is present in core biopsy material, surgical excision of the area is performed. The excision specimen is entirely submitted or extensively sampled, with special attention to the area adjacent to the biopsy site. If no obvious carcinoma is found in the excision specimen, excision and core biopsy slides should be reviewed together, whenever possible, to ensure that the atypical ductal proliferation is evaluated in its entirety. The rate of upgrade of ADH found in a core biopsy ranges from 15% to 30%, depending on the number and size of the cores.

Am J Clin Pathol. 2007;127:124–127. 11. Plantade R, Hammou JC, Fighiera M, et al. Underestimation of breast carcinoma with 11-gauge stereotactically guided directional vacuum-assisted biopsy. J Radiol. 2004;85:391–401. 12. Darling ML, Smith DN, Lester SC, et al. Atypical ductal hyperplasia and ductal carcinoma in situ as revealed by large-core needle breast biopsy: results of surgical excision. AJR Am J Roentgenol. 2000;175:1341–1346. 13. Jackman RJ, Nowels KW, Shepard MJ, et al. Stereotaxic large-core needle biopsy of 450 nonpalpable breast lesions with surgical correlation in lesions with cancer or atypical hyperplasia.

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