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Diagnostic Lymph Node Pathology (Hodder Arnold Publication) by Dennis H. Wright, Bruce J. Addis, Anthony S.-Y. Leong

By Dennis H. Wright, Bruce J. Addis, Anthony S.-Y. Leong

"Diagnostic Lymph Node Pathology" is a finished and generously illustrated advisor, making it the fitting useful reference booklet. The overseas crew of very hot haematopathologists write in an authoritative and available variety with an emphasis on morphological overview in addition to immunohistochemistry. The publication truly and logically provides the factors for differential analysis with illustrations of either classical and no more famous good points of every ailment method. this may turn out to be a necessary advisor for all surgical pathologists and haematopathologists focused on reading lymph node biopsies and may be a useful studying textual content for histopathologists in education.

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Extra info for Diagnostic Lymph Node Pathology (Hodder Arnold Publication)

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Patients with MCD have a poor prognosis. The node shows follicular hyperplasia with numerous red (pyroninophilic) plasma cells in the medullary cords. The deep basophilia of the plasma cell cytoplasm highlights these cells in the medullary cords. 3 ‘Gold lymphadenopathy’. Axillary lymph node from a patient with rheumatoid disease treated with colloidal gold. Black pigment is seen within histiocytes. 4 ‘Gold lymphadenopathy’ viewed in polarized light showing characteristic orange–red birefringence.

In the acute infection, the virus replicates in perifollicular B-cells, stimulating a vigorous humoral and cellular immune response. Involved lymph nodes are enlarged but not matted. They may show varying degrees of follicular hyperplasia but the most striking feature is paracortical expansion. Large numbers of blast cells, many of immunoblast morphology, are seen within the paracortex. Immunohistochemistry shows that these are of both B- and T-cell phenotype. Occasionally, atypical cells and cells resembling Hodgkin/Reed–Sternberg cells are seen.

The stains may often reveal myriads of bacilli similar to the globi of lepromatous leprosy that can be seen as basophilic cytoplasmic streaks in H&E sections. In tuberculoid leprosy, the nodes show discrete epithelioid granulomas with a variable number of Langhans giant cells but without necrosis. The granulomas may undergo fibrosis and hyalinization, and may mimic sarcoidosis. The lepromatous form of the disease gives rise to a striking paracortical histiocytosis with large clusters of the bacilli or globi within the foam cells, also called lepra cells or Virchow cells.

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