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Ciba Foundation Symposium 126 - Selective Neuronal Death

Parkinson's ailment, Alzheimer's affliction, and motor neuron ailment proportion an important universal function: selective demise of neurons in constrained areas of the mind. This foreign symposium, held through the Ciba starting place in 1986, is the 1st to compile neurophysiologists engaged on neuronal dying and neuropathologists facing human degenerative mind sickness. contributors describe the reasons and series of occasions resulting in neuronal dying and talk about what could be performed to avoid it. one of the issues coated are fresh advances within the knowing of brokers similar to trophic elements, excitotoxins and poisons which are identified to be considering neuronal dying; examples of neuronal dying in the course of common improvement; and the function performed by way of endocrine mechanisms and neuronal job. additionally considers trophic elements controlling the survival of neuronal transplants and the healing customers for tissue transplantation.

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Brain Res 324:394-396 Struble RG, Powers RE, Casanova MF, Kitt CA, O’Connor DT, Price DL 1985a Multiple transmitter-specific markers in senile plaques in Alzheimer’s disease. SOC Neurosci Abstr 11:953 Struble RG, Price DL Jr, Cork LC, Price DL 1985b Senile plaques in cortex of aged normal monkeys. Brain Res 361:267-275 Struble RG, Lehmann J , Mitchell ST et a1 1986 Cortical cholinergic innervation: distribution and source in monkeys. In: Hanin I (ed) Dynamics of cholinergic function. Plenum Press, New York, in press Swanson LW, Sawchenko PE, Rivier J, Vale WW 1983 Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study.

J Natl Cancer Inst 61:645-656 Schoenberg BS, Anderson DW, Haerer AF 1985 Prevalence of Parkinson’s disease in the biracial population of Copiah County, Mississippi. Neurology 352341-845 Ward CD, Duvoisin RC, Ince SE, Nutt JD, Eldridge R, Calne DB 1983 Parkinson’s disease in 65 pairs of twins and in a set of quadruplets. Neurology 33:815-824 Wisniewski HM, Rabe A 1986 Discrepancy between Alzheimer-type neuropathology and dementia in people with Down syndrome. Ann NY Acad Sci, in press Novartis Foundation Symposium Edited by GregoIy Bock, Maeve O’Connor Copyright 0 1987 by Ciba Foundation Dysfunction and death of neurons in human degenerative neurological diseases and in animal models DONALD L.

J Neurol Sci 59:277-289 Carpenter S 1968 Proximal axonal enlargement in motor neuron disease. Neurology 18:841-851 Cork LC, Griffin JW, Munnell JF, Lorenz MD, Adams RJ, Price DL 1979 Hereditary canine spinal muscular atrophy, J Neuropathol Exp Neurol 38:209-221 Cork LC, Griffin JW, Choy C, Padula CA, Price DL 1982 Pathology of motor neurons in accelerated hereditary canine spinal muscular atrophy. Lab Invest 46:89-99 Cork LC, Sternberger NH, Sternberger LA, Casanova MF, Struble RG, Price DL 1986 Phosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer’s disease.

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