By Sami Shousha
This e-book covers sensible diagnostic concerns in breast pathology, with precise emphasis on parts which pose diagnostic problems. those contain facing the gross specimens derived from sufferers taken care of with conservative surgical procedure and those that had neo-adjuvant treatment earlier than surgical procedure. It additionally discusses the way to care for axillary lymph nodes, proliferative breast lesions, together with DCIS, and not easy center biopsies, in addition to fibro-epithelial, spindle phone, lobular, mucinous, metaplastic and papillary lesions, molecular class of breast cancers, breast lesions in male sufferers and breast immunohistochemistry. there's a concentrate on strange benign and malignant breast lesions and lots of fine quality photographs support the reader diagnose tricky cases.
Breast Pathology: problematical Issues is aimed toward histopathology experts and senior trainees who take care of breast pathology.
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Additional resources for Breast Pathology: Problematic Issues
E. Pinder 40 Fig. 14 Flat epithelial atypia (FEA). High-power magnification of an expanded acinar space lined by multilayered (but flat and non-architecturally atypical) epithelium formed from uniform cells with round, monotonous nuclei Columnar cell change and columnar cell hyperplasia are regarded as benign and require no further investigation when identified in a core biopsy (see Chap. 4). Flat epithelial atypia is often seen in association with other lesions of the low-grade neoplasia family, including lobular neoplasia and ADH/low-grade DCIS , and these should be carefully sought if FEA is seen in any specimen.
Nature. 1984;312:513–6. 76. Baselga J, Tripathy D, Mendelsohn J, Baughman S, Benz CC, Dantis L, et al. Phase II study of weekly intravenous recombinant humanized anti-p185 HER2 monoclonal antibody in patients with HER2/neuoverexpressing metastatic breast cancer. J Clin Oncol. 1996;14:737–44. 32 77. Shepard HM, Lewis GD, Sarup JC, Fendly BM, Maneval D, Mordenti J, et al. Monoclonal antibody therapy of human cancer: taking the HER2 protooncogene to the clinic. J Clin Immuno. 1991;11:117–1127. 78.
An architecturally atypical (largely cribriform) lowgrade epithelial proliferation is seen contained within this expanded space. Centrally, wide fibrovascular cores with overlying columnar-shaped epithelium are seen as part of the preexisting papilloma. The extent of the atypical proliferation was more than 3 mm, and this was therefore regarded as low-grade DCIS in a papilloma This author regards papillomas bearing DCIS as distinct from papillary carcinoma in situ, which are lesions with thin fibrovascular fronds and overlying perpendicularly arranged columnar-shaped neoplastic epithelial cells but without an interspersed myoepithelial layer.