By Frances P. O'Malley, Sarah E. Pinder, Anne Marie Mulligan
Breast Pathology, a name within the Foundations in Diagnostic Pathology sequence, offers all the such a lot crucial details at the pathological entities encountered in perform in an easy-to-use structure. Drs. Frances P. O'Malley, Sarah E. Pinder, and Anna Marie Mulligan offer unprecedented specialist counsel for the examine and prognosis of a vast spectrum of breast lesions in addition to the large diversity of appearances of standard breast tissue. The constant, useful layout with a wealth of illustrations, at-a-glance containers, and tables, besides on-line entry at www.expertconsult.com, make this name perfect for speedy reference for either beginners and skilled breast pathologists Reference key details quick and simply with a constant, straight forward layout and at-a-glance containers and tables through the textual content. learn all elements of a pathologic entity, together with scientific positive factors, pathologic good points (gross and microscopic), ancillary experiences, differential analysis, and prognostic and healing issues. trap the entire nuances of ways pathological lesions current via over four hundred full-color illustrations. perform with self belief and triumph over your hardest demanding situations with suggestion from the head minds in breast pathology. entry the absolutely searchable textual content on-line at www.expertconsult.com, besides a downloadable photograph financial institution, illustrations, packing containers, tables, and extra. follow the most recent molecular diagnostic options to acknowledge newly pointed out classifications in breast sickness. Get extra of the data you would like from new and elevated chapters masking a huge variety of illnesses and themes together with effective needle aspiration cytology and the actual dealing with of middle biopsy specimens; dealing with and overview of sentinel lymph nodes; ailments of the male breast; and state of the art insurance of molecular advances in malignant breast disorder. organize for the way forward for breast pathology with a brand new bankruptcy devoted to gene profiling and stem mobile diagnostic ideas. a short and straightforward to take advantage of reference, as a refresher or for these simply beginning out, on breast pathology.
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Additional info for Breast Pathology: A Volume in the Foundations in Diagnostic Pathology Series (Second Edition)
Jacobs TW, Connolly JL, Schnitt SJ: Nonmalignant lesions in breast core needle biopsies: to excise or not to excise?. Am J Surg Pathol 2002; 26(9):1095-1110. Jacobs TW, Siziopikou KP, Prioleau JE, et al: Do prognostic marker studies on core needle biopsy specimens of breast carcinoma accurately reflect the marker status of the tumor?. Mod Pathol 1998; 11(3):259-264. Jaffer S, Nagi C, Bleiweiss IJ: Excision is indicated for intraductal papilloma of the breast diagnosed on core needle biopsy. Cancer 2009; 115(13):2837-2843.
For any sample, optimal fixation and processing of tissue and high-quality hematoxylin and eosin (H&E) stained sections are essential. Indeed, a small number of the more diagnostically difficult lesions that may be encountered in histopathology practice may be impossible to assess if optimal fixation, processing, section cutting, and staining have not been undertaken. Core biopsies can be performed with clinical or image-directed guidance methods, the latter under stereotactic mammography, ultrasound, or magnetic resonance imaging (MRI) guidance.
Neoadjuvant therapy, often chemotherapy, is typically given to reduce the size of a tumor mass and to either allow surgical excision (if previously inoperable or locally advanced) or enable breast-conserving surgery (rather than mastectomy) to be performed. In some cases, this may prove so effective that there is a complete pathologic response and no invasive carcinoma remains. More commonly, there is tumor shrinkage, which can, on occasions, make the lesion difficult to identify macroscopically and thus cause difficulties in specimen handling in the pathology laboratory.