By Barbara J. Bain, David M. Clark, Bridget S. Wilkins
Bone Marrow Pathology has been widely revised to mirror the numerous advances that have happened within the program of cytogenetics and particularly, molecular genetics within the analysis, category and figuring out of haematological issues. This entire ebook not just offers info on all universal illness entities, but in addition covers infrequent problems within which bone marrow exam turns out to be useful. it really is designed as functional source with ‘Problems and Pitfalls’ sections all through to help laboratory diagnosis.This fourth edition:Incorporates the ideas of the 2008 WHO class of Tumours of Haematopoietic and Lymphoid TissuesCovers key diagnostic ideas similar to move cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysisIncludes new diagnostic algorithms and precis boxesContains 550 color illustrations together with top quality electronic photomicrographs Haematologists and histopathologists will locate this e-book a useful machine reference whilst acting day-by-day blood and bone marrow investigations.
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Extra info for Bone Marrow Pathology, Fourth edition
50) are infrequent in normal bone marrow in which they rarely constitute more than 1% of nucleated cells. In healthy children they are even less frequent . They are distinctive cells with a diameter of 15–20 µm and an eccentric nucleus, moderately basophilic cytoplasm and a prominent paranuclear Golgi zone. The cytoplasm may contain occasional vacuoles and sometimes stains pink with a May–Grünwald–Giemsa (MGG) stain, consequent on the presence of carbohydrate. The nuclear chromatin shows prominent coarse clumps, although the clock-face chromatin pattern that is often discernible in histological sections is usually less apparent in films.
32). Megakaryocyte proliferation and platelet production are primarily regulated by interactions between thrombopoietin (TPO) and its cell surface receptor, MPL . An increased demand for platelets, for example due to peripheral destruction, leads to an increase in ploidy level and cell size, apparent in a bone marrow film as an increased volume of cytoplasm and a large, usually well- TH E N OR M A L B ON E M A R R OW 23 Fig. 32 Aspirate of normal BM: a late megakaryocyte which has shed most of its cytoplasm as platelets.
They are difficult to recognize in H&E-stained histological sections because the granules do not stain distinctively. They are readily recognizable in a Giemsa stain (Fig. 40) in which the granules stain metachromatically; their vivid purple colour make them conspicuous. Mast cell granules also give positive reactions for chloroacetate esterase, are periodic TH E N OR M A L B ON E M A R R OW 27 Fig. 40 Section of a trephine biopsy specimen from a patient with renal failure: a mast cell and maturing granulocytes.