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Bone Marrow Pathology (3rd Edition) by Barbara J. Bain, David M. Clark, Irvin A. Lampert, Bridget

By Barbara J. Bain, David M. Clark, Irvin A. Lampert, Bridget S. Wilkins

Written through one of many world's prime haematologists, and 3 well known histopathologists, Bone Marrow Pathology presents a finished advisor to the prognosis of bone marrow affliction. Now in its 3rd variation, the textual content has been generally revised and rewritten to mirror the newest advances within the box.

An tremendous functional, up to the moment textual content incorporating the hot WHO type of haematopoietic malignancies

A complete textual content written with nice precision and readability of style
Incorporates a brand new part 'Problems and Pitfalls' - a different part that would relief the operating pathologist confronted with a tricky situation

An vital textual content for the haematologist, histopathologist and haematopathologist with equivalent weight given to peripheral blood, aspirate, trephine biology and really expert techniques

Extensively illustrated with the various photos being of paraffin-embedded sections

Combines the entire concepts now utilized to bone marrow analysis, together with immunocytochemistry, move cytometery, immunohistochemistry and the diagnostic function of cytogenetic and molecular genetic analysis

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Extra resources for Bone Marrow Pathology (3rd Edition)

Example text

Similarly, examination of trephine biopsy sections in isolation permits detection of histomorphological abnormalities but not a full assessment of a case. The pathologist should beware of the risks of either over-interpreting biopsy findings or failing to offer an adequate interpretation because of lack of consideration of clinical and haematological features and aspirate findings. It is desirable that trephine biopsies are either reported by a haematopathologist who is also able to interpret bone marrow aspirates or that the histopathologist and haematologist examine aspirate films and biopsy sections together.

54 Crystals of glove powder in a BM aspirate. MGG ×376. result from a previous biopsy performed at the same site a short time before. Increased numbers of macrophages, including foamy macrophages, can be found. The scars of previous biopsies are usually apparent and repeat biopsies should be carried out from the other side of the pelvis or a centimetre or so away from any recent biopsy on the same side. It should also be noted that, if the pelvis has previously been irradiated, biopsies will show bone marrow hypoplasia or aplasia which is not indicative of the appearance of the bone marrow at other sites.

Haemosiderin can often be detected, particularly when it is increased, as golden brown refractile pigment in an unstained or H&E-stained section (Fig. 5). In a Giemsa-stained section it is greenish-blue (Fig. 6). An iron stain (Fig. 7) can be successfully carried out using either plasticembedded or paraffin-embedded biopsy specimens. However, plastic-embedded specimens give more reliable results. Decalcification of a paraffin-embedded specimen, whether by acid decalcification or by chelation, leads to some leaching out of iron.

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