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Bipolar Disorders: 2nd Stanley Symposium, Freiburg, November by J. Walden, H. Grunze

By J. Walden, H. Grunze

Complement factor: Neuropsychobiology 2002, Vol. forty five, Suppl. 1

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Extra resources for Bipolar Disorders: 2nd Stanley Symposium, Freiburg, November 2000 (Neuropsychobiology)

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Dittmann A. Forsthoff N. Matzner B. Amann H. Grunze Department of Psychiatry, LMU University Hospital, Munich, Germany Key Words Bipolar disorder W Schizoaffective disorder W Clozapine Abstract Atypical neuroleptics are increasingly used in the treatment of bipolar and schizoaffective disorders. Currently, numerous controlled short-term studies are available for clozapine, olanzapine, risperidone or quetiapine, but long-term data are still missing. Three patients (2 with bipolar disorder, 1 with schizoaffective disorder) are described who showed a marked reduction of affective symptomatology after clozapine had been added to mood stabilizer pretreatment.

Kraepelin’s statistic Long-Term Monitoring for Bipolar Disorder Neuropsychobiology 2002;45(suppl 1):27–32 One episode Two episodes Three or more episodes Depression Mania Mania and depression 263 120 57 102 24 23 106 89 115 29 To gain more insight into the patterns of the course of illness in bipolar affective disorder, in cooperation with J. Rehm, he developed a number of diagrams (fig. 2, 3): He used different colours for the bipolar mood swings as well as different shades and fill patterns according to the severity of illness.

The Social Rhythm Metric An established diagnosis-specific psychotherapy for bipolar disorder is not available yet. , 1997, 2000]. Clinical signs for an association of affective disor- Hörn/Schärer/Walser/Scherer-Klabunde/ Biedermann/Walden Fig. 4. Predictability of affective changes. Upper graph: activity index of the Social Rhythm Metric. Lower graph: mood score of the Adjective Mood Scale (higher values show severer depression). The steady increase in activity before the depressive episodes seems important for predictions (of course activity diminishes with the start of depression).

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