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Biochemistry, pathology, and genetics of pulmonary emphysema by Bignon, Jean; Scarpa, Giovanni Luigi

By Bignon, Jean; Scarpa, Giovanni Luigi

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Read or Download Biochemistry, pathology, and genetics of pulmonary emphysema : proceedings of an international symposium held in Sassari, Italy, 27-30 April 1980 PDF

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Additional resources for Biochemistry, pathology, and genetics of pulmonary emphysema : proceedings of an international symposium held in Sassari, Italy, 27-30 April 1980

Example text

Pulmonary emphysema and proteolysis. New York: Academic Press; 1972:439–447. 52. , KIMBEL, P. Induction of experimental emphysema in dogs using leukocyte homogenates. Amer. Rev. resp. Dis. 1971; 104:595–598. 53. P. Le système Pi et les états déficitaires en alpha1-antitrypsine. Nouv. Presse méd. 1973; 2:2375–2377. 54. C. Abnormal interaction of α1-antitrypsin and leukocyte elastolytic activity in patients with chronic obstructive pulmonary disease. Amer. Rev. resp. Dis. 1979; 120:411–419. 55. W.

Amer. Rev. resp. Dis. 1979; 119:941–951. 48. , ERIKSSON, S. The elecirophoretic cirglobulin pattern of serum in α1-antitrypsin deficiency. Scand. J. clin. Lab. Invest. 1963; 15:132–140. 49. B. Reaction of ozone with protease inhibitors from bovine pancreas, egg white, and human serum. Environ. Res. 1978; 16:179–190. 59 50. A. Inhibitors and activators of leukocytic proteases in purulent sputum: digestion of human lung and inhibition by alpha1-antitrypsin. J. Lab. clin. Med. 1971; 77:713–727. 51.

3 Schematic representation of the synthesis of elastic fibers in order to indicate how lathyrogens and D-penicillamine can work to induce emphysema. 3. Many exogenous irritants have been used to induce pulmonary emphysema in animals [13]. Nitrogen oxide- [22] and cadmium- [68] induced emphysema are useful models for understanding the mechanisms leading to various inflammatory reactions, the release of protease and to emphysematous changes, which are not yet clearly understood. 4. There is no strong evidence that an acute, systemic lung injury occurring, for example, after intravenous injection of an endotoxin can lead to pulmonary emphysema; however, in one experiment, repetitive insults with intravenously administered endotoxin for nine consecutive weeks induced a marked sequestration of pulmonary leukocytes and a slight increase in the alveolar linear intercept [76].

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