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Biophysics

Behavioral Neurobiology of Bipolar Disorder and its by Husseini K. Manji, Carlos A. Zarate Jr.

By Husseini K. Manji, Carlos A. Zarate Jr.

This e-book deals the main updated information regarding study surrounding the neurobiology of bipolar illness in addition to presently on hand and novel healing ideas. the amount has assembled a extensively revered staff of preclinical and scientific researchers who convey their services to undergo upon this affliction by way of reviewing state of the art examine and medical proof concerning the pathophysiology and therapy of bipolar ailment. Early chapters evaluate the direction and consequence and genetics of this hugely heritable situation, together with chapters on epigenetics and medical endophenotypes. a number of chapters supply a remarkably thorough and specified review of the neurobiology of the affliction, together with what's recognized from neuroimaging paintings and the advance of animal types. eventually, the e-book covers therapy recommendations for bipolar affliction, together with either conventional and novel therapeutics, in addition to non-pharmacological remedies. It deals either researchers and clinicians key insights into this devastating affliction.

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Extra resources for Behavioral Neurobiology of Bipolar Disorder and its Treatment (Current Topics in Behavioral Neurosciences, Volume 5)

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2 Family Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 3 Molecular Genetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Genetic Linkage and Candidate Gene Studies . . . . . . . . . . . . . . . . . . . 2 Genome Wide Association Studies . . . . . . . . . . . . . . . . . . . . . . . . 22 4 New Strategies in BPD Genetics Research .

Small RNAs are 21 28 nucleotides in length, and are derived from the cleavage of double-stranded RNA. Such RNAs can play a regulatory role at transcriptional and posttranscriptional levels. RNA-mediated gene silencing plays a pivotal role in maintaining chromosomal structure, genome defense, and gene regulation, and has recently been shown to play a significant role in disease progression (Almeida and Allshire 2005; Eckstein 2005; Guil and Esteller 2009; Mishima et al. 2009; Rosell et al. 2009).

McMahon Fig. 2 Key genome wide association findings in bipolar disorder (BPD) samples as of June 2010. Each finding is indicated by a box drawn near the chromosomal location of the associated marker(s) and annotated with the name of the nearest gene(s). Each study is assigned a unique color, but many of the samples reported to date contain overlapping individuals. org Genetics of Bipolar Disorder 25 heterogeneous entity at the clinical level, and it seems likely that at least several conditions, with distinct etiologies, comprise what we call BPD.

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