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Basic Concepts of Molecular Pathology by Philip T. Cagle (auth.), Timothy Craig Allen, Philip T.

By Philip T. Cagle (auth.), Timothy Craig Allen, Philip T. Cagle (eds.)

The Molecular Pathology Library sequence was once created to bridge the distance among conventional easy technological know-how textbooks in molecular biology and standard clinical textbooks for organ-specific ailments. uncomplicated options of Molecular Pathology is designed as a stand-alone publication to supply the pathologist, clinician or radiologist with a concise evaluate of the basic terminology, techniques and instruments of molecular biology which are utilized to the knowledge, analysis and therapy of human ailments within the age of custom-made medicine.

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2006;69:73–83. 157. Zhao Y, Sato Y, Isaji T, et al. Branched N-glycans regulate the biological functions of integrins and cadherins. FEBS J. 2008;275:1939–1948. 4 Apoptosis and Cell Death Pothana Saikumar and Manjeri A. Venkatachalam Introduction Alternative Forms of Cell Death Cell death plays a central role in multicellular organisms during their early development in sculpting the body parts and in their adult life by controlling cell numbers (homeostasis), and cell death further protects the organism overall by removing all cells damaged by disease, aging, infection, genetic mutation, and exposure to toxic agents.

Witta SE, Gemmill RM, Hirsch FR, et al. Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res. 2006;66: 944–950. 109. Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small cell lung cancer (the IDEAL 1 Trial). J Clin Oncol. 2003;21:2237–2246. 110. Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial.

T. Cagle mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med. 1999;5:662–668. Aoudjit F, Vuori K. Integrin signaling inhibits paclitaxelinduced apoptosis in breast cancer cells. Oncogene 2001;20: 4995–5004. Cordes N. Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity. Cancer Res. 2004;64: 5683–5692. Takeichi M. Cadherin cell adhesion receptors as morphogenetic regulator. Science. 1991;251:1451–1459. Kemler R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion.

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