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An Introduction to the Principles of Disease by J. B. Walter

By J. B. Walter

New version of this easy-to-read textual content has been up to date and revised to hide new details on scientific genetics, immune reaction, and comprises the most recent findings in AIDS. Acquaints the reader with primary elements of strong point parts together with bacteriology, biochemistry, hematology, radiology, and surgical procedure. in actual fact reproduced photographs, micrographs, and line drawings make clear recommendations provided within the textual content

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Examine Figure 2-2. The epithelial cells covering the villi are thought to arise in the crypts by mitosis. From there they migrate along the surface of the villi and are cast off finally from the tip. How would you attempt to confirm this movement and to measure the time taken for a cell to migrate from the crypt to the tip? 6. How many types of RNA are there in a cell? Indicate their main functions. 7. The genes that control the formation of the enzyme glucose-6-phosphate dehydrogenase (GPD) are situated on the X chromosome.

Thus, only hybrid cells containing a human X chromosome are capable of producing human type glucose-6-phosphate dehydrogenase (G6PD). T h e human type enzyme can be differentiated from mouse G 6 P D by electrophoresis (Chapter 25). It may be deduced that the gene coding for this enzyme is situated on the human X chromosome. Somatic Cell Hybridization Before describing the techniques and importance of gene cloning it is necessary to describe the properties of plasmids. Plasmids. Plasmids are small particles found in bacteria that consist of a circular double strand of DNA.

At least five different types of collagen are known, and these differ in the amino acid sequence of their constituent polypeptide chains (see below). They differ also in their distribution within the various tissues of the body. The collagens and ground substance are synthesized by fibroblasts and by similar cells such as are found in tendon, cornea, bone, and cartilage. Light-Microscopic Appearance of Collagene The first formed collagen consists of fine branching fibers called reticulin (Fig. 2-20).

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