By Herbert E. Spiegel (Eds.)
For greater than thirty years, this serial has broadened the technical scope and extended the medical base of scientific chemistry. those volumes make clear the parts of molecular biology and informatics and the tracking of physiological parameters in serious occasions as they pertain to medical chemistry. every one quantity of Advances in scientific Chemistry includes an index, and every bankruptcy comprises references.
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Additional resources for Advances in Clinical Chemistry, Vol. 36
Stained, and cleared. In contrast, polyacrylamide does not permit the separation of many macromolecules, which cannot penetrate the gel. The polyacrylamide gels can only be used 12 or more hours after polymerization. Finally, acrylamide is known to be toxic to laboratory workers (S1). 3. Analysis of IgG Oligoclonal Bands in the CSF Since the late 1960s and early 1970s, CSF protein electrophoresis has found an important application in the diagnosis of some diseases of the central nervous system.
1. CRP. Assessment of CSF CRP may become a useful parameter for distinguishing between septic and aseptic meningitis. Concentrations significantly increase in most cases of bacterial meningitis and are useful in separating acute bacterial from acute viral infections. When CSF CRP concentrations exceed the level of 120 μg L−1, the probability of bacterial infection is very high (C2). CRP shows a sensitivity of 80% in the diagnosis of bacterial meningitis (S13). 2. α 1-Microglobulin (AMG). AMG, a protein whose biological relevance has not yet been established, has not been investigated to date in CSF, 18 P.
The mean levels of Aβ 1–42 and τ -protein in CSF were significantly reduced (with high specificity and sensitivity) in patients in comparison to normal findings (M6). 8. S 100b Protein. S 100b protein is synthesized in astroglial cells and thus can be used as a reliable and sensitive marker for central nervous system damage. Measurements of S 100b protein are useful in the diagnosis and prognosis of acute stroke and in the estimation of ischemic brain damage during cardiac surgery (K4). 9. Tetranectin (TN).