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Acute and Chronic Cough (Lung Biology in Health and Disease, by Anthony E. Redington, Alyn H. Morice

By Anthony E. Redington, Alyn H. Morice

A finished evaluate of the medical and medical elements of acute and protracted cough, this reference makes a speciality of contemporary advancements in our knowing of the molecular biology of putative cough receptors, the neural mechanisms concerned with the afferent and efferent limbs, the principal processing of the cough reflex, and peptides and different ingredients that can mediate or modulate the cough reflex. With chapters wriitenby stated professionals within the box, this guide covers present and capability healing brokers, a number of methodologies to degree cough reflex sensitivity, and medical methods for the evaluation of power cough in adults and kids.

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Extra info for Acute and Chronic Cough (Lung Biology in Health and Disease, Volume 205)

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427 1 Molecular Biology of TRPV1 and Related Receptors SUN WOOK HWANG College of Medicine, Korea University, Seoul, South Korea Introduction Vagal C-fibers form a large majority of the afferent nerves innervating the lungs and airways. These nerves show similar properties to those of the cutaneous C-fibers of somatic sensory populations (dorsal root ganglia neurons) studied in relation to functional and anatomical aspects of nociceptive transmission (1–3). The axons of C-fibers conducting nociceptive signals are unmyelinated and their cell bodies are small in size.

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P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels maintains heat hyperalgesia. Neuron 2002; 36:57–68. 97. Guo A, Vulchanova L, Wang J, Li X, Elde R. Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 1999; 11:946–958. 22 Hwang 98. Nakatsuka T, Furue H, Yoshimura M, Gu JG. Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord.

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